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pBpF-AM, p-Benzoyl-L-Phenylalanine Acetoxymethyl ester hydrochloride

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Catalog: ASIS-0194

Formal Name: (acetyloxy)methyl(2S)-2-amino-3-(4-benzoylphenyl)propanoate hydroxochloride

Produced By: AsisChem, Inc.

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pdfASIS-0194 Technical Product Information (537.62 KB )

Biological Description

p-Benzoyl-L-Phenylalanine acetoxymethyl ester hydroxochloride (pBpF-AM*HCL), ASIS-0194, is a form of the unnatural amino acid (UAA) p-benzyoyl-phenylalanine. pBpF is a genetically encodable UAA which can be used to induce site specific photo crosslinking of any protein with an amber suppressor mutation technique (Rust, Subramanian et al. 2014). Site specific incorporation of pBpF relies upon an orthogonal tRNA and amino acyl tRNA synthetase derived from a Bacillus stearothermophilus amber suppressor tRNA and amino acyl synthetase found in the pEVOL-pBpF plasmid (Rust, Subramanian et al. 2014). Published experiments using the salt-free form of pBpF cite a working concentration of 0.25-0.5 mM in E. coli C43(DE3). pBpF has also been used in mammalian cell culture (Bray, Mouledous et al. 2014, Valentin-Hansen, Park et al. 2014)..

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Additional Information

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Catalog ASIS-0194
Formal Name (acetyloxy)methyl(2S)-2-amino-3-(4-benzoylphenyl)propanoate hydroxochloride
CAS Number No
Molecular Weight 341.37
Formula C19H19NO5
Lead Time 4 weeks
LogP No
Purity No
SMILES c1cc(ccc1)C(=O)c1ccc(cc1)C[C@H](N)C(=O)OCOC(=O)C
Solubility and Handling No
inchikey JPYFYEICANLWPJ-KRWDZBQOSA-N
TPSA No
HBD 1
HBA 6

Details

Bray, L., L. Mouledous, J. A. Tafani, M. Germanier and J. M. Zajac (2014). "A high-affinity, radioiodinatable neuropeptide FF analogue incorporating a photolabile p-(4-hydroxybenzoyl)phenylalanine." Anal Biochem 453: 50-54 (Abstract).

Rust, H. L., V. Subramanian, G. M. West, D. D. Young, P. G. Schultz and P. R. Thompson (2014). "Using unnatural amino acid mutagenesis to probe the regulation of PRMT1." ACS Chem Biol 9(3): 649-655 (Abstract).

Valentin-Hansen, L., M. Park, T. Huber, A. Grunbeck, S. Naganathan, T. W. Schwartz and T. P. Sakmar (2014). "Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid." J Biol Chem 289(26): 18045-18054 (Abstract).

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You're reviewing: pBpF-AM, p-Benzoyl-L-Phenylalanine Acetoxymethyl ester hydrochloride

Product Details

Additional Information

Quantities Please contact us for larger or different quantities
Catalog ASIS-0194
Formal Name (acetyloxy)methyl(2S)-2-amino-3-(4-benzoylphenyl)propanoate hydroxochloride
CAS Number No
Molecular Weight 341.37
Formula C19H19NO5
Lead Time 4 weeks
LogP No
Purity No
SMILES c1cc(ccc1)C(=O)c1ccc(cc1)C[C@H](N)C(=O)OCOC(=O)C
Solubility and Handling No
inchikey JPYFYEICANLWPJ-KRWDZBQOSA-N
TPSA No
HBD 1
HBA 6
References

Details

Bray, L., L. Mouledous, J. A. Tafani, M. Germanier and J. M. Zajac (2014). "A high-affinity, radioiodinatable neuropeptide FF analogue incorporating a photolabile p-(4-hydroxybenzoyl)phenylalanine." Anal Biochem 453: 50-54 (Abstract).

Rust, H. L., V. Subramanian, G. M. West, D. D. Young, P. G. Schultz and P. R. Thompson (2014). "Using unnatural amino acid mutagenesis to probe the regulation of PRMT1." ACS Chem Biol 9(3): 649-655 (Abstract).

Valentin-Hansen, L., M. Park, T. Huber, A. Grunbeck, S. Naganathan, T. W. Schwartz and T. P. Sakmar (2014). "Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid." J Biol Chem 289(26): 18045-18054 (Abstract).

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