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(S)-demethylphosphinothricin hydrochloride (DMPT hydrochloride)

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Availability: In stock

Catalog: ASIS-0069

Formal Name: (2S)-2-amino-4-(hydroxyphosphinyl)-butanoic acid hydrochloride

Produced By: AsisChem, Inc.

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pdfASIS-0069 SDS.pdf (93 KB )

Biological Description

(S)-demethylphosphinothricin hydrochloride (DMPT) is a catalyst and methyl acceptor for cobalamin-dependent methyltransferases (Class B Radical SAM methyltransferases (RSMTs) (Allen & Wang, 2014). In Streptomyces hygroscopicus, Streptomyces viridochromogenes, and Kitasatospora phosalacinea, this reaction produces L-Phosphinothricin, or glufosinate, an amino acid and glutamate analog (Allen & Wang, 2014; Hu, Werner, Allen, & Wang, 2015; Li et al., 2015). Glufosinate and its derivatives are only molecules in nature known to contain C-P-C linkages (Werner et al., 2011). L-phosphinothricin has herbicidal and antimicrobial properties through its ability to inhibit glutamate synthesis (Werner et al., 2011) and is the key to Liberty Link herbicide resistance in crops.Class B RSMTs are heavily linked to antibiotic biosynthesis (Werner et al., 2011). As a precursor to L-phosphinothricin, NAcDMPT is used to study PhpK and other RSMTs. Recent research suggests Shewanella denitrificans also catalyzes a L-Phosphinothricin reaction to produce a phosphinate natural product (Allen & Wang, 2014). DMPT and other methyl acceptors like NAcDMPT (ASIS-0068) are useful tools for evaluating the activity of RSMTs and may enable the discovery of novel antimicrobials.

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Additional Information

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Catalog ASIS-0069
Formal Name (2S)-2-amino-4-(hydroxyphosphinyl)-butanoic acid hydrochloride
CAS Number 85178-62-7
Molecular Weight 167.10026550293
Formula C4 H10 N O4 P
Lead Time 1
LogP -0.044300001
Purity 95
SMILES [C@@H](N)(C(O)=O)CCP([H])(O)=O |&1:0|
Solubility and Handling No
inchikey IDBRULKICVRMNG-VKHMYHEASA-N
TPSA 124.0899963
HBD 4
HBA 5

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Additional Information

Quantities Please contact us for larger or different quantities
Catalog ASIS-0069
Formal Name (2S)-2-amino-4-(hydroxyphosphinyl)-butanoic acid hydrochloride
CAS Number 85178-62-7
Molecular Weight 167.10026550293
Formula C4 H10 N O4 P
Lead Time 1
LogP -0.044300001
Purity 95
SMILES [C@@H](N)(C(O)=O)CCP([H])(O)=O |&1:0|
Solubility and Handling No
inchikey IDBRULKICVRMNG-VKHMYHEASA-N
TPSA 124.0899963
HBD 4
HBA 5
References

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