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Bis(2-ethylhexyl) Tetrabromophthalate

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Catalog: ASIS-0002

Formal Name: Bis(2-ethylhexyl) Tetrabromophthalate; 3,4,5,6-tetrabromobenzene-1,2-dicarboxylic acid

Produced By: AsisChem, Inc.

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pdfASIS-0002 Technical Product Information.pdf (525.91 KB )

Biological Description

TBPH is one of two primary components in the novel brominated flame retardant, Firemaster 550 (Roberts et al. 2012, Springer et al. 2012, Fic et al. 2014). Widespread use of these novel flame retardants has lead to an increase in human exposure to this new family of chemicals and little research has been done on their chronic effects on human health (Springer et al. 2012). While TBPH is not thought to be an endocrine disrupting chemical, its primary metabolite is associated with both anti-estrogenic and anti-androgenic effects (Roberts et al. 2012). Exposure of pregnant female rats to TBMEHP, the primary metabolite, at a dose of 200 or 500 mg/kg lead to dose dependent increases in hypothyroidism, hepatotoxicity, and an increase in male fetus multinucleated germ cells associated with fetal testes toxicity (Springer et al. 2012).

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Additional Information

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Catalog ASIS-0002
Formal Name Bis(2-ethylhexyl) Tetrabromophthalate; 3,4,5,6-tetrabromobenzene-1,2-dicarboxylic acid
CAS Number 26040-51-7
Molecular Weight 706.140380859375
Formula C24 H34 Br4 O4
Lead Time 3
LogP 9.48
Purity 95
SMILES C1(C(Br)=C(C(=O)OCC(CC)CCCC)C(C(=O)OCC(CC)CCCC)=C(Br)C=1Br)Br
Solubility and Handling No
inchikey UUEDINPOVKWVAZ-UHFFFAOYSA-N
TPSA 52.6
HBD 0
HBA 4

Details

Fic, A., B. Zegura, D. Gramec and L. P. Masic (2014). "Estrogenic and androgenic activities of TBBA and TBMEPH, metabolites of novel brominated flame retardants, and selected bisphenols, using the XenoScreen XL YES/YAS assay." Chemosphere 112: 362-369. (http://www.ncbi.nlm.nih.gov/pubmed/25048928)(Abstract)

Roberts, S. C., L. J. Macaulay and H. M. Stapleton (2012). "In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues." Chem Res Toxicol 25(7): 1435-1441. (http://www.ncbi.nlm.nih.gov/pubmed/22575079)(Abstract)

Springer, C., E. Dere, S. J. Hall, E. V. McDonnell, S. C. Roberts, C. M. Butt, H. M. Stapleton, D. J. Watkins, M. D. McClean, T. F. Webster, J. J. Schlezinger and K. Boekelheide (2012). "Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust." Environ Health Perspect 120(12): 1711-1719. (http://www.ncbi.nlm.nih.gov/pubmed/23014847)(Abstract)

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Product Details

Additional Information

Quantities Please contact us for larger or different quantities
Catalog ASIS-0002
Formal Name Bis(2-ethylhexyl) Tetrabromophthalate; 3,4,5,6-tetrabromobenzene-1,2-dicarboxylic acid
CAS Number 26040-51-7
Molecular Weight 706.140380859375
Formula C24 H34 Br4 O4
Lead Time 3
LogP 9.48
Purity 95
SMILES C1(C(Br)=C(C(=O)OCC(CC)CCCC)C(C(=O)OCC(CC)CCCC)=C(Br)C=1Br)Br
Solubility and Handling No
inchikey UUEDINPOVKWVAZ-UHFFFAOYSA-N
TPSA 52.6
HBD 0
HBA 4
References

Details

Fic, A., B. Zegura, D. Gramec and L. P. Masic (2014). "Estrogenic and androgenic activities of TBBA and TBMEPH, metabolites of novel brominated flame retardants, and selected bisphenols, using the XenoScreen XL YES/YAS assay." Chemosphere 112: 362-369. (http://www.ncbi.nlm.nih.gov/pubmed/25048928)(Abstract)

Roberts, S. C., L. J. Macaulay and H. M. Stapleton (2012). "In vitro metabolism of the brominated flame retardants 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) and bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate (TBPH) in human and rat tissues." Chem Res Toxicol 25(7): 1435-1441. (http://www.ncbi.nlm.nih.gov/pubmed/22575079)(Abstract)

Springer, C., E. Dere, S. J. Hall, E. V. McDonnell, S. C. Roberts, C. M. Butt, H. M. Stapleton, D. J. Watkins, M. D. McClean, T. F. Webster, J. J. Schlezinger and K. Boekelheide (2012). "Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust." Environ Health Perspect 120(12): 1711-1719. (http://www.ncbi.nlm.nih.gov/pubmed/23014847)(Abstract)

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